Protected: Doxy PEP: A New Strategy to Prevent STIs Did you know that you can protect yourself from sexually transmitted infections (STIs) after unprotected sex? An antibiotic called doxycycline can reduce your risk of common bacterial STIs by more than half if taken within 72 hours of sexual activity. When used this way, it is referred to as doxy post-exposure prophylaxis (PEP). This content is password protected. To view it please enter your password below: Password: Additional ResourcesVirginia Department of Health - “Doxy PEP for STI Prevention”ReferencesCenters for Disease Control and Prevention - “Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024”Virginia Department of Health - “Doxy PEP for STI Prevention”